Autophagy, Mitochondrial Dynamics, and Retinal Diseases
نویسندگان
چکیده
منابع مشابه
Mitochondrial Dynamics in Mitochondrial Diseases
Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission/fusion, movements and turnover, are essential for the mitochondrial network quality control. Alterations in mitochondrial dynamics can cause neuropathies such as Charcot-Marie-Tooth disease in which mitochondrial f...
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Cells normally respond to a lack of nutrients by activating autophagy, a prominent pro-survival pathway that involves the catabolism and recycling of cytoplasmic material. Recent results indicate that mitochondria actively elongate during autophagy, thereby avoiding their degradation and sustaining cell viability.
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Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslatio...
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Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), ...
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Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...
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ژورنال
عنوان ژورنال: Asia-Pacific Journal of Ophthalmology
سال: 2013
ISSN: 2162-0989
DOI: 10.1097/apo.0b013e31829d3e33