منابع مشابه
Autophagy and innate immunity.
munity-related GTPase M) and NOD2 (nucleotide-binding oligomerization domain 2)] results in the development of immune-related diseases, such as Crohn’s disease, a chronic inflammatory bowel disease [2] . Autophagy represents an ancient immune defense strategy present in flies. Importantly, as flies lack an adaptive immune system, the function of autophagy in cellintrinsic innate immunity can be...
متن کاملPathogen-induced autophagy signaling in innate immunity.
Innate immunity induces rapid responses to fight invading pathogens. To eliminate intracellular bacteria or viruses, innate cellular responses lead to the production of nuclear factor-κB-dependent inflammatory cytokines, inflammasome activation, type I interferon synthesis, and/or eventually death of the infected cells. Autophagy emerged as another component of innate immunity, as it offers an ...
متن کاملVirus-Induced Autophagy in Innate Immunity
When a virus invades a host cell, autophagy is triggered to maintain cellular homeostasis. Virus-induced autophagy is a double-edged sword in the antiviral function of host innate immunity. Unlike apoptosis, autophagy plays a different role in cell survival or inducing cell death. This mini-review summarizes recent developments in our understanding of the antiviral roles of autophagy in host in...
متن کاملBacterial Invasion: Linking Autophagy and Innate Immunity
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
متن کاملOzone and pulmonary innate immunity.
Ambient ozone (O(3)) is a commonly encountered environmental air pollutant with considerable impact on public health. Many other inhaled environmental toxicants can substantially affect pulmonary immune responses. Therefore, it is of considerable interest to better understand the complex interaction between environmental airway irritants and immunologically based human disease. The innate immun...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2019
ISSN: 1662-811X,1662-8128
DOI: 10.1159/000497414