منابع مشابه
Drug Induced Liver Toxicity: a Survey
Liver toxicity refers to damage done to the liver by medications and chemicals. The liver is an essential organ to the human body. Located on the right side of the body behind the ribs, the liver stores nutrients and produces proteins important to remain healthy. One of the main functions of the liver is to remove toxic substances from the bloodstream. This process may be interrupted if toxins ...
متن کاملAbacavir-induced liver toxicity.
Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir di...
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In the recent era, use of various nutritional supplements is highly encouraged amongst the people of United States. Weight loss supplements are major part of the nutritional supplements and their usage is unregulated in the US. Obesity is a major health concern in the US and Americans spend around $30 billion a year for weight loss supplements. At times, these supplements can be responsible for...
متن کاملDrug-induced liver toxicity studies: research into human metabolites clarifies their role in drug development.
On January 1, 2014, Professor Hiroshi Yamazaki became the fourth Editor-in-Chief of Drug Metabolism and Pharmacokinetics (DMPK), the official journal of the Japanese Society for the Study of Xenobiotics (JSSX). The former Editors-in-Chief, Professors Masahiro Hayashi, Kan Chiba, and Ikumi Tamai, and their editorial teams did a tremendous job in setting up and developing DMPK into the successful...
متن کاملIncreased autophagy accelerates colchicine-induced muscle toxicity.
Colchicine treatment is associated with an autophagic vacuolar myopathy in human patients. The presumed mechanism of colchicine-induced myotoxicity is the destabilization of the microtubule system that leads to impaired autophagosome-lysosome fusion and the accumulation of autophagic vacuoles. Using the MTOR inhibitor rapamycin we augmented colchicine’s myotoxic effect by increasing the autopha...
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ژورنال
عنوان ژورنال: Journal of Food and Drug Analysis
سال: 2014
ISSN: 1021-9498
DOI: 10.1016/j.jfda.2014.03.007