منابع مشابه
Autophagy and innate immunity.
munity-related GTPase M) and NOD2 (nucleotide-binding oligomerization domain 2)] results in the development of immune-related diseases, such as Crohn’s disease, a chronic inflammatory bowel disease [2] . Autophagy represents an ancient immune defense strategy present in flies. Importantly, as flies lack an adaptive immune system, the function of autophagy in cellintrinsic innate immunity can be...
متن کاملPlant Innate Immunity
The ability to discriminate between selfand nonself-molecules is characteristic of all living organisms. This feature forms the basis for the activation of innate immune responses uponmicrobial attack. Ifmicrobes bypass the external physical barrier, plants have evolved two classes of immune receptors to detect nonself-molecules to prevent further pathogen progress. One class consists of membra...
متن کاملBacterial Invasion: Linking Autophagy and Innate Immunity
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
متن کاملLipopolysaccharides and plant innate immunity.
Plants posses an innate immune system that has many parallels with those found in mammals and insects. A range of molecules of microbial origin called Microbe Associated Molecular Patterns (MAMPs) act to trigger basal defense responses in plants. These elicitors include lipopolysaccharides (LPS) from diverse Gram-negative bacteria. Both core oligosaccharide and the lipid A moieties of LPS as we...
متن کاملPathogen-induced autophagy signaling in innate immunity.
Innate immunity induces rapid responses to fight invading pathogens. To eliminate intracellular bacteria or viruses, innate cellular responses lead to the production of nuclear factor-κB-dependent inflammatory cytokines, inflammasome activation, type I interferon synthesis, and/or eventually death of the infected cells. Autophagy emerged as another component of innate immunity, as it offers an ...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2006
ISSN: 1462-5814,1462-5822
DOI: 10.1111/j.1462-5822.2006.00715.x