Autophagy and cell death in model organisms
نویسندگان
چکیده
منابع مشابه
Autophagy and cell death.
Autophagy is a physiological and evolutionarily conserved phenomenon maintaining homeostatic functions like protein degradation and organelle turnover. It is rapidly upregulated under conditions leading to cellular stress, such as nutrient or growth factor deprivation, providing an alternative source of intracellular building blocks and substrates for energy generation to enable continuous cell...
متن کاملAutophagy and cell death.
Autophagy is intimately associated with eukaryotic cell death and apoptosis. Indeed, in some cases the same proteins control both autophagy and apoptosis. Apoptotic signalling can regulate autophagy and conversely autophagy can regulate apoptosis (and most likely other cell death mechanisms). However, the molecular connections between autophagy and cell death are complicated and, in different c...
متن کاملAutophagy, cell death, and cancer
Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to the lysosome. Increasing evidence reveals that autophagic dysfunction is associated with human diseases, such as cancer. Paradoxically, although autophagy is well recognized as a cell survival process that promotes ...
متن کاملAutophagy and cell death in Caenorhabditis elegans.
Cell death is a major component of developmental programs. Controlled killing of specific cells at appropriate time points is required for normal growth and shaping of organisms. However, cellular demolition can also result in a variety of pathologies that are frequently fatal, when implemented inappropriately. Delineation of cell death mechanisms has been greatly facilitated by the use of simp...
متن کاملAutophagy in cell death: an innocent convict?
The visualization of autophagosomes in dying cells has led to the belief that autophagy is a nonapoptotic form of programmed cell death. This concept has now been evaluated using cells and organisms deficient in autophagy genes. Most evidence indicates that, at least in cells with intact apoptotic machinery, autophagy is primarily a pro-survival rather than a pro-death mechanism. This review su...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2008
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2008.120