Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling

An autonomous metabolomic workflow combining mass spectrometry analysis with tandem mass spectrometry data acquisition was designed to allow for simultaneous data processing and metabolite characterization. Although previously tandem mass spectrometry data have been generated on the fly, the experiments described herein combine this technology with the bioinformatic resources of XCMS and METLIN...

متن کامل

Metabolomics and metabolite profiling.

During the last 15 years, metabolomics has emerged as the latest of the so-called “omics” research fields. It deals with the analytical characterization of the metabolome, i.e. the low molecular weight metabolite complement of the biological system under investigation. A wide range of biological systems have benefited from metabolomics studies, from relatively simple microbes to plants and comp...

متن کامل

A New Paradigm for Known Metabolite Identification in Metabonomics/Metabolomics: Metabolite Identification Efficiency

A new paradigm is proposed for assessing confidence in the identification of known metabolites in metabonomics studies using NMR spectroscopy approaches. This new paradigm is based upon the analysis of the amount of metabolite identification information retrieved from NMR spectra relative to the molecular size of the metabolite. Several new indices are proposed including: metabolite identificat...

متن کامل

MIDAS: a database-searching algorithm for metabolite identification in metabolomics.

A database searching approach can be used for metabolite identification in metabolomics by matching measured tandem mass spectra (MS/MS) against the predicted fragments of metabolites in a database. Here, we present the open-source MIDAS algorithm (Metabolite Identification via Database Searching). To evaluate a metabolite-spectrum match (MSM), MIDAS first enumerates possible fragments from a m...

متن کامل

Metabolomics and metabolite profiling: past heroes and future developments.

Following the sequencing of the human and other genomes, much research effort is now invested in post- genomic science, particularly in the related disciplines of proteomics and metabolomics. In this paper, we will attempt to provide an overview of mass spectrometry-based metabolomic strategies, discuss the evolution of metabolomics from its predecessor, Hmetabolite profiling", and provide some...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2014

ISSN: 0003-2700,1520-6882

DOI: 10.1021/ac5025649