Automated Lead Discovery and Development in HTS Datasets
نویسندگان
چکیده
منابع مشابه
Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology.
Genetic target validation studies have demonstrated that the apoptosis signal-regulating kinase 1 (ASK1) represents an important target for the treatment of rheumatoid arthritis, cardiac diseases, and several neurodegenerative disorders. To identify small-molecule inhibitors of ASK1, we have developed a high-throughput screening-compatible, homogenous, biochemical assay using AlphaScreen techno...
متن کاملDiscovery and Development of a Style-Making Figure
Styles in the normal course of historical development change and evolve, and in the process of this movement and change, some poets play a vital role. These poets try to be inventive in order to escape banality and repeated and shallow literary traditions, and by creating a rift between themselves and former traditions they introduce new elements. These artists either create new figures o...
متن کاملDiscovery and development of metallocene-based polyolefins with special properties
Beside Ziegler-Natta and Phillips catalysts the development of methylaluminoxane (MAO) as cocatalyst in combination with metallocenes or other transition metal complexes for the polymerization of olefins has widely increased the possibilities in controlling the polymer composition, polymer structure, tacticity and special properties with high precision. These catalysts allow the synthesis of is...
متن کاملDevelopment of HTS Transformers and a 10 kVA HTS Transformer Prototype Design
⎯With the improvement of high temperature superconductor (HTS) practical performance, research and development concerning the applications of HTS transformers have been progressed actively worldwide. This paper provides a comprehensive summary on various HTS transformers, and studies the design of a single-phase 10 kVA (220V/24V) HTS transformer prototype to verify HTS for practical transformer...
متن کاملModern drug discovery technologies: opportunities and challenges in lead discovery.
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have revitalized the screening process model and emphasized the importance of exploring the intrinsic complementary nature of classical and modern methods in drug research. In this cont...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JALA: Journal of the Association for Laboratory Automation
سال: 2001
ISSN: 1535-5535
DOI: 10.1016/s1535-5535-04-00129-7