Autoimmunity, autoinflammation and kidney

Systemic autoimmune and autoinflammatory disease are associated with all types of diffuse kidney disease, that is, glomerulonephritis (including rapidly progressive), thrombotic microangiopathy, tubulointerstitial nephritis, AA-amyloidosis. However, the occurrence nephropathies differ significantly in patients various systemic immunemediated inflammatory diseases. For example, is one leading manifestation lupus erythematosus small-vessels vasculitis, angiopathy occurs frequently both primary secondary antiphosholipid syndrome, nephritis found Sjogren syndrome IgG4-associated whereas AA-amyloidosis can complicate rheumatoid arthritis, ankylosing spondilytis, psoriatic familial Meditarranean fever, certain other monogenic Over last decades, renal survival diseases improved due to earlier diagnosis development effective immunosuppressive anti-inflammatory treatments. a proportion still present progressive impairment function be unrelated activity underlying