Autoimmune susceptibility imposed by public TCRβ chains

Autoimmune susceptibility imposed by public TCRβ chains

Although the TCR repertoire is highly diverse, a small fraction of TCR chains, referred to as public, preferentially form and are shared by most individuals. Prior studies indicated that public TCRβ may be preferentially deployed in autoimmunity. We hypothesized that if these TCRβ modulate the likelihood of a TCRαβ heterodimer productively engaging autoantigen, because they are widely present i...

Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.

Characterizing the TCRα and TCRβ chains expressed by T cells responding to a given pathogen or underlying autoimmunity helps in the development of vaccines and immunotherapies, respectively. However, our understanding of complementary TCRα and TCRβ chain utilization is very limited for pathogen- and autoantigen-induced immunity. To address this problem, we have developed a multiplex nested RT-P...

Expression of the Autoimmune Susceptibility

Imposed cost induced by traffic injuries on society in 2021

  Background and Aim: Due to the importance of the cost of traffic  injuries, in addition to mental and social suffering, as well as the increasing trend of accident statistics and the lack of information about the cost estimation based on a willingness to pay model, this research was conducted on the findings of traffic injuries in 2021. Materials and Methods: The research was done by descr...

OCTN genes: Susceptibility genes for autoimmune diseases?

El estudio genético de las enfermedades autoinmunes de base poligénica (artritis reumatoide, enfermedad inflamatoria intestinal, etc) ha evolucionado desde la identificación, mediante estudios de ligamiento, de regiones del genoma implicadas en la susceptibilidad, a la identificación dentro de esas zonas, mediante estudios de asociación, de las variantes concretas en genes específicos que están...