Autoimmune Lymphoproliferative Syndrome Misdiagnosed as Hemophagocytic Lymphohistiocytosis
نویسندگان
چکیده
منابع مشابه
Autoimmune Lymphoproliferative Syndrome Misdiagnosed as Hemophagocytic Lymphohistiocytosis A Case Report
Autoimmune lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of apoptosis. It usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. Herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before ALPS was diagnosed for the patient. This case should alert pediatricians to consi...
متن کاملAutoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis.
Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder of apoptosis, most commonly due to mutations in the FAS (TNFRSF6) gene. It presents with chronic lymphadenopathy, splenomegaly, and symptomatic multilineage cytopenias in an otherwise healthy child. Unfortunately, these clinical findings are also noted in other childhood lymphoproliferative conditions, such as leukemia,...
متن کاملautoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis a case report
autoimmune lymphoproliferative syndrome (alps) is a rare inherited disorder of apoptosis. it usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before alps was diagnosed for the patient. this case should alert pediatricians to consi...
متن کاملIs hemophagocytic lymphohistiocytosis an autoimmune disease?
2. Oldenburg J, Quenzel E-M, Harbrecht U, et al. Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy. Br J Haematol. 1997;98: 240-244. 3. Oldenburg J, Kriz K, Wuillemin WA, et al. Genetic predisposition to bleeding during oral anticoagulant therapy: evidence for common founder mutati...
متن کاملDeath from Hemophagocytic Lymphohistiocytosis Syndrome Due to Generalized Hemorrhage
Hemophagocytic lymphohistiocytosis (HLH) is the result of excessive cytokine release, leading to over-response by immune cells, such as macrophages and T lymphocytes. Here, we report a lethal case of HLH with a complete clinical course. The patient was a 45-year-old man with fever and chills since two months ago plus splenomegaly, hepatomegaly, and pancytopenia. The Anti-HBc IgM was positive, b...
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ژورنال
عنوان ژورنال: Pediatrics
سال: 2013
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2012-2748