منابع مشابه
Caspr2 autoantibodies target multiple epitopes
OBJECTIVE To better understand the mechanisms of autoantibodies to the axonal protein contactin-associated protein-like 2 (Caspr2) by studying their target epitopes. METHODS A plasmid for expressing Caspr2 was modified so that the various extracellular subdomains were deleted individually and in groups. Cultured cells were transfected to express these constructs and assayed by immunofluoresce...
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Sir, We have read with great interest the McGonigal et al. (2010) article, which addresses the pathogenic role of GD1a antibodies and complement activation for node of Ranvier dysfunction. Nodal injury might explain several electrophysiological features and clinical symptoms in patients with Guillain–Barré syndrome including the sometimes rapid recovery from paralysis. In our opinion, the repor...
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1 Department of Basic and Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Bari, Italy, 2 Department of Medical Sciences, Gerontology Section, University of Torino, Torino, Italy, 3 Department of Pediatrics, University of Messina, Messina, Italy, 4 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy, ...
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Autoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this study was to clarify the origin of anti-C1q by determin...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2012
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2835