Autoacetylation of the Histone Acetyltransferase Rtt109
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چکیده
منابع مشابه
1 Autoacetylation of the Histone Acetyltransferase Rtt
AUTOACETYLATION OF THE HISTONE ACETYLTRANSFERASE RTT109* Brittany N. Albaugh, Kevin M. Arnold, Susan Lee, John M. Denu From Department of Biomolecular Chemistry and the Wisconsin Institute Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715 Running head: Regulation of Rtt109 by autoacetylation Address correspondence to: John M. Denu Ph.D., 2140 Wisconsin Institute of Discovery,...
متن کاملCatalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.
Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1. Here, we utilize biochemical, structural, and genetic analyses to pro...
متن کامل1 Autoacetylation of the Histone Acetyltransferase Rtt 109
AUTOACETYLATION OF THE HISTONE ACETYLTRANSFERASE RTT109* Brittany N. Albaugh, Kevin M. Arnold, Susan Lee, John M. Denu From Department of Biomolecular Chemistry and the Wisconsin Institute Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715 Running head: Regulation of Rtt109 by autoacetylation Address correspondence to: John M. Denu Ph.D., 2140 Wisconsin Institute of Discovery,...
متن کاملHistone acetyltransferase Rtt109 is required for Candida albicans pathogenesis.
Candida albicans is a ubiquitous opportunistic pathogen that is the most prevalent cause of hospital-acquired fungal infections. In mammalian hosts, C. albicans is engulfed by phagocytes that attack the pathogen with DNA-damaging reactive oxygen species (ROS). Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organis...
متن کاملAutoacetylation of the MYST Lysine Acetyltransferase MOF
The MYST family of histone acetyltransferases (HATs) plays critical roles in diverse cellular processes, such as the epigenetic regulation of gene expression. Lysine autoacetylation of the MYST HATs has received considerable attention recently. Nonetheless, the mechanism and function of the autoacetylation process are not well defined. To better understand the biochemical mechanism of MYST auto...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.251579