Authors’ reply to Baker and Alderson

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The family rule: a reply to Alderson.

The Authors’ Reply

Reply to Baker and Holtom.

TO THE EDITOR—We thank Drs Baker and Holtom [1] for their thoughtful comments on the low number of smear-negative, culture-positive tuberculosis cases in our study [2] and another recent study [3] of the GeneXpert MTB/RIF assay (Xpert). They astutely point out that this may have led us to underestimate the potential benefit of Xpert in low-burden settings. We agree that the incremental sensitiv...

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