Austrian Syndrome Caused by Highly Penicillin-Resistant Streptococcus pneumoniae

Penicillin-resistant Streptococcus Pneumoniae

Streptococcus pneumoniae is a major cause of pneumonia, meningitis, septicemia, acute otitis media, and other serious infections, severely affecting infants, young children, and the elderly. In the past, S. pneumoniae was uniformly susceptible to penicillin, which remained the drug of choice for serious infections. However, since the mid-1960s, resistance to penicillin, which was first reported...

Infection of pacemaker lead by penicillin-resistant Streptococcus Pneumoniae.

Penicillin-resistant Streptococcus pneumoniae (PRSP) infections have steadily increased worldwide; however, there are only a few reports of permanent pacemaker-related infections caused by PRSP. Here, we describe a patient who developed 7 episodes of endocarditis and sepsis from PRSP infection of the pacemaker lead in the right atrium. By periodic administration of vancomycin and extraction of ...

Invasive Disease Caused by Streptococcus Pneumoniae Resistant to Penicillin and Third-generation Cephalosporins

Clindamycin therapy of experimental meningitis caused by penicillin- and cephalosporin-resistant Streptococcus pneumoniae.

Although penicillin resistance among Streptococcus pneumoniae strains is increasing in many areas, resistance to clindamycin remains low. In our well-characterized rabbit meningitis model, we conducted experiments to evaluate the bacteriologic efficacy of clindamycin after a penicillin- and cephalosporin-resistant S. pneumoniae strain was intracisternally inoculated. Animals received a loading ...

Clinical characteristics of pneumonia caused by penicillin resistant and sensitive Streptococcus pneumoniae in Japan.

BACKGROUND S. pneumoniae is the leading cause of morbidity and mortality worldwide. P-lactam antibiotics were very effective against S. pneumoniae, however resistance to this class of antibiotic has become an increasing problem. OBJECTIVES To assess the clinical differences between penicillin-sensitive and penicillin-resistant pneumococcal pneumonia. METHODS The medical records of 306 patie...