Aurora A’s Functions During Mitotic Exit: The Guess Who Game
نویسندگان
چکیده
منابع مشابه
Aurora A’s Functions During Mitotic Exit: The Guess Who Game
Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments o...
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The correct assembly and timely disassembly of the mitotic spindle is crucial for the propagation of the genome during cell division. Aurora kinases play a central role in orchestrating bipolar spindle establishment, chromosome alignment and segregation. In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and t...
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What is it? The mitotic exit network – commonly known by the acronym MEN — is a signal transduction cascade which triggers the exit of mitosis. The MEN has been characterized in the budding yeast Saccharomyces cerevisiae, and the protein names below refer to components from this species, though many are conserved in vertebrates. The main switch of this cascade is the small G protein Tem1 and it...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2015
ISSN: 2234-943X
DOI: 10.3389/fonc.2015.00290