Aureoquinone, a New Protease Inhibitor from Aureobasidium sp.
نویسندگان
چکیده
منابع مشابه
Phevalin, a new calpain inhibitor, from a Streptomyces sp.
Calpain is a Ca2 + -dependent cysteine protease which is found in the microsomal and cytosolic compartments of most mammalianneurons and other cells1}. Calpain hydrolyses peptide bonds of proteins in the cytosol2'3). A large amount of research effort has been focused on this enzyme, since it potentially plays a central role in several physiological events, such as turnover of myofibrillar prote...
متن کاملVinaxanthone, a new FabI inhibitor from Penicillium sp.
OBJECTIVES Bacterial enoyl-ACP reductase (FabI) has been validated as a novel antibacterial target for tackling infections caused by multidrug-resistant pathogens. A few FabI inhibitors, however, are known. This study isolated a new FabI inhibitor from Penicillium sp. METHODS A screening programme led to the selection of a Penicillium sp. producing a strong FabI-inhibitory metabolite. The che...
متن کاملInhibition of xyloglucanase from an alkalothermophilic Thermomonospora sp. by a peptidic aspartic protease inhibitor from Penicillium sp. VM24.
A bifunctional inhibitor from Penicillium sp VM24 causing inactivation of xyloglucanase from Thermomonospora sp and an aspartic protease from Aspergillus saitoi was identified. Steady state kinetics studies of xyloglucanase and the inhibitor revealed an irreversible, non-competitive, two-step inhibition mechanism with IC(50) and K(i) values of 780 and 500nM respectively. The interaction of o-ph...
متن کاملOptimization of alkaline protease production from a locally isolated Bacillus sp. ZR-5: Potential application as a detergent additive
The aim of this study was to optimize protease production using a novel Bacillus sp. ZR-5 strainisolated from the soil, and evaluate its application in detergent industry. The proteolytic activityof the strain was demonstrated using gelatin hydrolysis screening test. Protease productionoptimization was carried out using a two-step approach: a conventional method in order toidentify the best car...
متن کاملA novel strain of Aureobasidium sp. TeO12 for theophylline production from caffeine
A total of 40 fungal cultures were isolated for their ability to grow on caffeine as a sole source carbon and nitrogen, and further screened for theophylline-producing activities under the growing cell system. Based on thin-layer chromatography and high-performance liquid chromatography analyses, the potent strain Aureobasidium sp. TeO12 was chosen for its capability to generate theophylline vi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2000
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.53.1293