Augmented HER-2–Specific Immunity during Treatment with Trastuzumab and Chemotherapy
نویسندگان
چکیده
منابع مشابه
Chemotherapy with or without trastuzumab.
The prognosis of pT1N0M0/stage I breast cancer has generally been considered so favourable that these patients are not routinely offered adjuvant systemic therapy. However, biological heterogeneity within pT1N0M0 dictates diverse outcomes within the subgroup. HER2 gene amplification or protein overexpression is uncommon in pT1N0M0 disease, but, when present, is clearly associated with a higher ...
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QUESTION One of my patients has been diagnosed with breast cancer and started treatment with trastuzumab. She has recently discovered that she is pregnant and wishes to continue the pregnancy. What are the consequences of trastuzumab treatment during pregnancy and can she continue her pregnancy? ANSWER Human data regarding the safety of trastuzumab during pregnancy are scarce. Only 3 case rep...
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Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoper...
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N. Maurea1, C. Coppola2, G. Piscopo2, D. Rea3, F. Galletta2, C. Maurea2, I. Capasso4, C. Arra3, R.V. Iaffaioli5 Cardiology, INT Pascale Naples, Naples, ITALY Cardiology, National Cancer Institute, Pascale Foundation, Naples, ITALY Animal Experimental Research, National Cancer Institute, Pascale Foundation, Naples, ITALY Breast Oncology Division, National Cancer Institute, Pascale Foundation, Na...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2007
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-07-0507