Augmentation of cognitive function in epilepsy

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Augmentation of cognitive function in epilepsy

Epilepsy is one of the most common neurological disorders in humans afflicting more than 1% of the population and 65 million people worldwide (England et al., 2012). The most common form of acquired epilepsy is temporal lobe epilepsy (TLE), and over 30% of patients with TLE have seizures that are refractory to commonly used anticonvulsant drugs (Bauer and Burr, 2001). Mesial temporal lobe scler...

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Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients with epilepsy. Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlle...

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Most children with epilepsy are of normal intelligence. However, a significant subset will have temporary or permanent cognitive impairment. Factors that affect cognitive function are myriad and include the underlying neuropathology of the epilepsy, seizures, epileptiform discharges, psychosocial problems, age at seizure onset, duration of epilepsy, and side effects associated with antiepilepti...

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ژورنال

عنوان ژورنال: Frontiers in Systems Neuroscience

سال: 2014

ISSN: 1662-5137

DOI: 10.3389/fnsys.2014.00147