Atypical Multiple Myelomatosis

Multiple myelomatosis with proptosis.

MULTIPLE myelomata are uncommon endosteal tumours developing from the myeloblastic elements of the bone marrow. The ribs, sternum, clavicle, vertebral bodies, and pelvis are favourite sites; the skull is also frequently involved and the long bones may be affected, but never alone (Perkins, 1936). The disease has an insidious onset and is often only recognized late when multiple nodules appear o...

May 1948 STEVENSON - : Multiple Myelomatosis

Bear this disease in mind when treating pains of the limbs of an obscure and intractable character.' This was said by Thos. Blizard Curling, F.R.S., Surgeon to the London Hospital, to William Macintyre i00 years ago. The quotation is from the paper in which Macintyre published at his leisure in i850 the clinical history of a case which had been noted to have ' urine of high density containing m...

Abnormal lipoproteins in multiple myelomatosis.

In a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins, named paralipoproteins (p-Lp), in 24 out of 30 normolipidaemic patients. These paralipoproteins were grouped according to their mobility into one or another of the following types: (1) p-Lp1 with a mobility identical with that of gamma-globulin, (2) p-Lp2 with a mobility b...

Ophthalmological complications of multiple myelomatosis.

Adult Fanconi syndrome and multiple myelomatosis.

A case is described of a 59-year-old woman presenting with multiple renal tubular defects. The aminoaciduria was of a generalized type. When investigated initially the only feature of myelomatosis was urinary Bence-Jones protein. Two years later radiologically classical multiple myelomatosis developed and rapidly progressed to the patient's death nine months later.