Atypical Antipsychotics and Neuroleptic Malignant Syndrome: Dear Editor

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Atypical neuroleptic malignant syndrome or serotonin toxicity associated with atypical antipsychotics?

Atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) have been prescribed extensively, often in combination with each other. When toxic encephalopathy develops with neuromuscular and autonomic symptoms in a patient taking medication including atypical antipsychotics, it has tended to be diagnosed as neuroleptic malignant syndrome (NMS). However, there have recently been s...

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Neuroleptic malignant syndrome and atypical antipsychotic drugs.

OBJECTIVE The incidence of neuroleptic malignant syndrome (NMS) is not known, but the frequency of its occurrence with conventional antipsychotic agents has been reported to vary from 0.02% to 2.44%. DATA SOURCES MEDLINE search conducted in January 2003 and review of references within the retrieved articles. DATA SYNTHESIS Our MEDLINE research yielded 68 cases (21 females and 47 males) of N...

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Drug information update. Atypical antipsychotics and neuroleptic malignant syndrome: nuances and pragmatics of the association

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of antipsychotics. Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS. The clinical profile of NMS caused b...

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Olanzapine-Induced Neuroleptic Malignant Syndrome

Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drug...

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Two cases of neuroleptic malignant syndrome in elderly patients taking atypical antipsychotics

SUMMARY Neuroleptic malignant syndrome (NMS) is a rare, life-threatening adverse reaction to antipsychotic medication that typically includes high-fever, extrapyramidal symptoms, autonomic nervous system dysfunction and disturbances in consciousness. Though reported to be more common following use of the older, first generation antipsychotic medications, it can also occur in patients taking the...

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ژورنال

عنوان ژورنال: The Canadian Journal of Psychiatry

سال: 2001

ISSN: 0706-7437,1497-0015

DOI: 10.1177/070674370104600923