Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with single dose dexmedetomidine in controlled hypertensive patients: prospective randomized double-blind study

Abstract Background Laryngoscopy and endotracheal intubation may be associated with adverse events as hypertension, tachycardia, increased serum concentrations of catecholamines. These are serious in patients cardiac diseases or hypertension. This work was designed to assess the effects single dose dexmedetomidine on hemodynamic response controlled hypertensive patients. Methods Seventy were randomly assigned into two equal groups; dexmed group received intravenous 0.5 mcg/kg diluted 20 ml 0.9% sodium chloride control chloride. Changes heart rate, systolic, diastolic, mean blood pressures recorded both groups at baseline, after 5 min study drug infusion, 3 induction prior intubation, 1 intubation. Results Dexmed had a significantly lower systolic pressure, diastolic pressure min, Conclusions Single attenuated laryngoscopy Trial registration ClinicalTrial.Gov ( NCT03204006 ) (March2018).