Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase
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چکیده
منابع مشابه
Phosphorylated-p38 mitogen-activated protein kinase expression is associated with clinical factors in invasive breast cancer
PURPOSE P38 mitogen-activated protein kinases (MAPK) level is an important prognostic factor in breast cancer. This study was performed to detect the expressions of P-p38 MAPK expression in breast cancer and explore their correlations with clinicopathological factors. EXPERIMENTAL DESIGN Tumor samples from 355 Chinese patients diagnosed with invasive breast cancer and adjacent non-cancerous t...
متن کاملTitle: Increased Phosphorylated p38 Mitogen Activated Protein Kinase in COPD
The p38 Mitogen Activated Protein Kinase (MAPK) pathway is upregulated in COPD. To date dual-labelling to identify cell-type specific presence of phosphorylated (phospho-) p38 MAPK has not been carried out. Phospho-p38 MAPK was quantified in a variety of cell types in the lung tissue of 20 COPD patients, 12 smokers and 12 non-smokers using immunohistochemistry. Paired blood and sputum neutrophi...
متن کاملIncreased phosphorylated p38 mitogen-activated protein kinase in COPD lungs.
The p38 mitogen-activated protein kinase (MAPK) pathway is upregulated in chronic obstructive pulmonary disease (COPD). To date, dual labelling to identify cell-type-specific presence of phosphorylated (phospho-)p38 MAPK has not been carried out. Phospho-p38 MAPK was quantified in a variety of cell types in the lung tissue of 20 COPD patients, 12 smokers and 12 nonsmokers using immunohistochemi...
متن کاملAnti-inflammatory Effects of Oxymatrine Through Inhibition of Nuclear Factor–kappa B and Mitogen-activated Protein Kinase Activation in Lipopolysaccharide-induced BV2 Microglia Cells
Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes. This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...
متن کاملAnti-inflammatory Effects of Oxymatrine Through Inhibition of Nuclear Factor–kappa B and Mitogen-activated Protein Kinase Activation in Lipopolysaccharide-induced BV2 Microglia Cells
Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes. This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...
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ژورنال
عنوان ژورنال: Journal of Ethnopharmacology
سال: 2005
ISSN: 0378-8741
DOI: 10.1016/j.jep.2005.01.026