Attenuated amyloid-β aggregation and neurotoxicity owing to methionine oxidation
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چکیده
منابع مشابه
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation.
Aggregation of the amyloid-beta (Abeta) peptide into amyloid plaques is a characteristic feature of Alzheimer's disease neuropathogenesis. We and others have previously demonstrated delayed Abeta aggregation as a consequence of oxidizing a single methionine residue at position 35 (Met-35). Here, we examined the consequences of Met-35 oxidation on the extremely aggregation-prone peptides Abeta1-...
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ژورنال
عنوان ژورنال: NeuroReport
سال: 2007
ISSN: 0959-4965
DOI: 10.1097/wnr.0b013e3280b07c21