Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia

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Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the possible cross talk between PAR-2 and capsaicin receptors, we investigated if PAR-2 activation could facilitate capsaicin-evoked visceral pain and referred hyperalgesia in the mouse and also examined the effect of PAR-1 activation in this mod...

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Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.

BACKGROUND Although the preclinical literature suggests that cannabinoids produce antinociception and antihyperalgesic effects, efficacy in the human pain state remains unclear. Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin. METHODS In a randomized, double-blinded, placebo-controlle...

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Tourniquet constriction exacerbates hyperalgesia-related pain induced by intradermal capsaicin injection.

BACKGROUND When capsaicin is injected intradermally, hyperalgesia develops around the injection site. The authors observed that volunteers report painful sensations in the skin remote from the injection site during tourniquet constriction of the affected extremity. METHODS Each volunteer received an intradermal injection of capsaicin on the volar forearm, followed by intermittent tourniquet c...

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ژورنال

عنوان ژورنال: Frontiers in Systems Neuroscience

سال: 2009

ISSN: 1662-5137

DOI: 10.3389/conf.neuro.01.2009.04.034