ATP-Sensitive Potassium Channels Modulate Glucose Transport in Cultured Human Skeletal Muscle Cells.
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چکیده
منابع مشابه
ATP-Sensitive Potassium Channels Modulate Transport in Cultured Human Skeletal Muscle Glucose Cells
Several lines of evidence suggest that ATP-sensitive potassium (KATP) channels are involved in glucose uptake by insulin target tissues. The aim of the present study was to prove directly the effect of KATP channel activity on glucose transport into cultured human skeletal muscle cells. We used potassium channel openers PCO400 and nicorandil alone or in combination with channel blockers glibenc...
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ATP-sensitive potassium (K(ATP)) channels are known to be critical in the control of both insulin and glucagon secretion, the major hormones in the maintenance of glucose homeostasis. The involvement of K(ATP) channels in glucose uptake in the target tissues of insulin, however, is not known. We show here that Kir6.2(-/-) mice lacking Kir6.2, the pore-forming subunit of these channels, have no ...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2001
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.48.369