ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity
نویسندگان
چکیده
منابع مشابه
ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity.
Ion channels are found in a variety of cancer cells and necessary for cell cycle and cell proliferation. The roles of K(+) channels in the process are, however, poorly understood. In the present study, we report that adenosine triphosphate (ATP)-sensitive potassium channel activity plays a critical role in the proliferation of glioma cells. The expression of K(ATP) channels in glioma tissues wa...
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Sulfonylurea drugs stimulate endogenous insulin secretion by blockade of ATP-sensitive potassium channels in pancreatic beta cells. These drugs are widely used in the treatment of type 2 diabetes. However, as ATP-sensitive potassium channels also exist in cardiomyocytes and coronary and peripheral arterial vascular smooth muscle cells, sulfonylurea drug usage in theory may cause unwanted cardio...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2009
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgp034