Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness
نویسندگان
چکیده
منابع مشابه
Atopy, airway responsiveness, and genes.
Asthma is a manifestation of bronchial hyperreactivity (BHR) and forms part of the spectrum of atopic disease. Some pedigree studies of atopy have suggested linkage with the high-affinity IgE receptor (FcE RI1) gene on chromosome 11q13, but others find no linkage. The molecular genetics of asthma and BHR have not been studied in the general population. We examined the genetic linkage of the Fce...
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Airway responsiveness is an objectively measurable clinical trait related to the presence of asthma. Although risk factors for this trait have been evaluated cross-sectionally, little is known about its longitudinal predictors. A population cohort of 539 children, aged 8 yrs at the start of follow-up, underwent 3-7 bronchial challenge tests spaced at 3-9 month intervals. Airway responsiveness w...
متن کاملParental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma.
BACKGROUND Previous studies have not resolved the importance of several potential risk factors for the development of childhood atopy, airway hyperresponsiveness, and wheezing, which would allow the rational selection of interventions to reduce morbidity from asthma. Risk factors for these disorders were examined in a birth cohort of 1037 New Zealand children. METHODS Responses to questions o...
متن کاملPulmonary physiology, airway responsiveness and asthma.
What we know: Tests that have allowed the measurement of lung function in infants have greatly enhanced our understanding of early pulmonary development and the pathophysiology of early respiratory disease. Airway responsiveness in infancy appears to be an independent determinant of symptoms and lung function later in childhood. New tests of airway responsiveness hold the promise of predicting,...
متن کاملShort paper Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma
Background—Sputum eosinophil counts and exhaled nitric oxide (NO) levels are increased in asthma and both measurements fall in response to corticosteroids. Methods—Exhaled NO levels and sputum eosinophil counts were assessed as noninvasive markers of the response to an oral steroid in 37 patients (19 women) with stable chronic asthma (mean (SD) age 48.6 (12.2) years, asthma duration 25.9 (17.3)...
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ژورنال
عنوان ژورنال: Pediatric Pulmonology
سال: 2013
ISSN: 8755-6863
DOI: 10.1002/ppul.22784