Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors

Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim this study was to explore long-term association between AR, AC, asthma, specific immunoglobulin E (IgE) blood platelet leukocyte differential counts. In Danish Blood Donor Study, 14,440 participants from Central Denmark Region had counts available completed a questionnaire regarding asthma. Of these participants, 8485 were tested for IgE inhalation allergens. prevalence sensitization 19%, 15%, 9%, 29%, respectively. wheeze, associated with increased eosinophil concentration even in sensitized who did not report any allergy or strongest associations observed current disease. We found no differences months without symptoms AR wheezing, allergens concentration. This may reflect persistent inflammation periods symptomatic