ATM is usually rearranged in T-cell prolymphocytic leukaemia
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منابع مشابه
Bendamustine is effective in T-cell prolymphocytic leukaemia.
T-cell prolymphocytic leukaemia (T-PLL) is an aggressive T-cell neoplasm with a mature post-thymic T-cell phenotype. Most patients present with markedly elevated leucocyte counts, splenomegaly, lymphadenopathy, hepatomegaly, skin lesions, pleuroperitoneal effusions or central nervous system involvement (Matutes et al, 1991). The most frequent chromosome abnormalities in T-PLL are inv(14)(q11q32...
متن کاملT-Cell Prolymphocytic Leukaemia: A Case Series
T-prolymphocytic leukaemia (T-PLL) is a rare mature T-cell lymphoproliferative disorder. It is seen more often in middle-aged and elderly individuals with a median age of onset of 65 years and a male predominance of 2:1. Patients present with hepatosplenomegaly, lymphadenopathy, 15% may have serous effusions and approximately 20% have skin involvement. The white cell count is often above 200 x ...
متن کاملInactivation of the ATM gene in T-cell prolymphocytic leukemias.
T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong predisposition of AT patients to develop T-PLL and the high frequency of T-cell...
متن کاملT-cell Prolymphocytic Leukemia.
BACKGROUND: T-cell prolymphocytic leukemia (T-PLL) is a post-thymic T-cell malignancy with aggressive clinical course. Although T-PLL has been referred to under different designations, it is a distinct clinico-biological entity and should be distinguished from other T-cell disorders. METHODS: The literature on T-PLL is reviewed. Experience on the clinical and laboratory features, differential d...
متن کاملT-cell prolymphocytic leukemia.
T-cell prolymphocytic leukemia is a rare and unusual malignancy characterized by the proliferation of small- to medium-sized prolymphocytes of postthymic origin with distinctive clinical, morphologic, immunophenotypic, and cytogenetic features. Involvement of the peripheral blood, bone marrow, lymph nodes, liver, spleen, and skin can occur. The clinical course is typically very aggressive with ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1998
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1201603