Atherogenic Impact of Homocysteine: Can HMG-CoA Reductase Inhibitors Additionally Influence Hyperhomocysteinaemia?
نویسندگان
چکیده
منابع مشابه
Pharmacology of the HMG-CoA reductase inhibitors
Pleiotropic effects are now described for the 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammatory and immune-modulatory effects. An extensive in vitro data set defines roles...
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Experimental Evidence for a Role of Dyslipidemia in Renal Injury and for a Renal Protective Effect of Statins T he presence of lipids in renal cells upregulates intracellular signaling pathways involved in inflammatory and fibrogenic responses, both of which are components of progressive renal injury. Lipids activate various growth factors that cause mesangial cell proliferation. Mesangial cell...
متن کاملRenal tubular toxicity of HMG-CoA reductase inhibitors.
A patient developed direct renal tubular toxicity on high-dose HMG-CoA reductase inhibitor (statin) therapy. Considerable renal damage was present by the time the injury became apparent. Urine abnormalities regressed after stopping the drug and reappeared after about 2 weeks following re-challenge. Although tubular damage may be slight and relatively difficult to detect, it is possible that cum...
متن کاملPleiotropic effects of the HMG-CoA reductase inhibitors
The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to furth...
متن کاملModulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy.
3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Several large landmark clinical studies have shown a marked reduction of cardiovascular mortality and morbidity in patients treated with statins. Because of the strong association between serum cholesterol levels and coronary artery diseas...
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ژورنال
عنوان ژورنال: Serbian Journal of Experimental and Clinical Research
سال: 2019
ISSN: 2335-075X,1820-8665
DOI: 10.1515/sjecr-2017-0055