ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1
نویسندگان
چکیده
منابع مشابه
Extracellular chaperones and proteostasis.
There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but growing family of constitutively secreted extrac...
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یکی از مسایل مهم در یادگیری زبان ، یادگیری لغت است. هدف این تحقیق ، بررسی یاد گیری شیوه های مستقیم و غیر مستقیم فراگیری لغت درفرایند شنیداری زبان است و اینکه کدامیک از آنها برای بهبود و تسهیل یادگیری واژگان زبان آموزان سطح متوسطه موثرترند.این تحقیق تفاوت بین تاثیر فراگیری مستقیم و غیر مستقیم لغت در فرایند شنیداری زبان در کوتاه مدت را بررسی می کند ، سپس تفاوت بین تاثیر یادگیری مستقیم و غیر مستقی...
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Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecules for their effects on cell size. We find that statins, inhibitors of the mevalonate pathway, reduce cell proliferation and increase cell size and...
متن کاملProtein Folding and Mechanisms of Proteostasis
Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that modula...
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ژورنال
عنوان ژورنال: iScience
سال: 2021
ISSN: 2589-0042
DOI: 10.1016/j.isci.2021.102315