ATG Interviews Ann Okerson

Hepatotoxicity induced by horse ATG and reversed by rabbit ATG: a case report

BACKGROUND The use of antilymphocyte agents has improved patient and graft survival in hematopoietic stem cell and solid organ transplantation but has been associated with the development of short-term toxicities as well as long-term complications. CASE PRESENTATION We report a young female with Fanconi anemia who received antithymocyte globulin as part of the conditioning regimen prior to he...

The Temporal Rover and the ATG Rover

The Temporal Rover is a specification based verification tool for applications written in C, C++, Java, Verilog and VHDL. The tool combines formal specification, using Linear-Time Temporal Logic (LTL) and Metric Temporal Logic (MTL), with conventional simulation/execution based testing. The Temporal Rover is tailored for the verification of complex protocols and reactive systems where behavior ...

Unstructured Interviews

Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.

Regulatory T cells (Treg) play important roles in suppressing immune responses and maintaining tolerance. Rabbit antithymocyte globulin (rATG) and horse ATG (hATG) are widely used in the treatment of immune-mediated syndromes, but their effects on Treg are unknown. We show here that in vitro culture of normal human peripheral blood mononuclear cells (PBMCs) with a low-dose rATG resulted in mark...

Ann Harrison