منابع مشابه
Shirin Doroudgar and Christopher C. Glembotski Stress Response Atf6 and Thrombospondin 4 : the Dynamic Duo of the Adaptive Endoplasmic Reticulum
Stress Response ATF6 and Thrombospondin 4 : The Dynamic Duo of the Adaptive Endoplasmic Reticulum Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/CIRCRESAHA.112.28056
متن کاملProangiogenic Properties of Thrombospondin-4.
OBJECTIVE Thrombospondin-4 (TSP-4) is 1 of the 5 members of the thrombospondin protein family. TSP-1 and TSP-2 are potent antiangiogenic proteins. However, angiogenic properties of the 3 other TSPs, which do not contain the domains associated with the antiangiogeneic activity of TSP-1 and TSP-2, have not been explored. In our previous studies, we found that TSP-4 is expressed in the vascular ma...
متن کاملIdentification and characterization of thrombospondin-4, a new member of the thrombospondin gene family
A new member of the thrombospondin gene family, designated thrombospondin-4, has been identified in the Xenopus laevis genome. The predicted amino acid sequence indicates that the protein is similar to the other members of this gene family in the structure of the type 3 repeats and the COOH-terminal domain. Thrombospondin-4 contains four type 2 repeats and lacks the type 1 repeats that are foun...
متن کاملMolecular Medicine Thrombospondin-4 Regulates Vascular Inflammation and Atherogenesis
Rationale: Thrombospondin (TSP)-4 is an extracellular protein that has been linked to several cardiovascular pathologies. However, a role for TSP-4 in vascular wall biology remains unknown. Objective: We have examined the effects of TSP-4 gene (Thbs4) knockout on the development of atherosclerotic lesions in ApoE / mice. Methods and Results: Deficiency in TSP-4 reduced atherosclerotic lesions: ...
متن کاملThrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood. In a post-gene chip microarray effort to identify new target genes contributing to neuropathic pain development, we report here the characterization of a novel neuropathic pain contributor, thrombospondin-4 (TSP4), using a neuropathic pain model of spinal nerve ligation injury. TSP4 is m...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.280560