ASYMMETRIC REDUCTION OF KETONES WITH A CATIONIC CHIRAL PHOSPHINE RHODIUM COMPLEX CATALYST

Cationic Rhodium Complexes with Hemilabile Phosphine Ligands as Polymerization Catalyst for High Molecular Weight Stereoregular Polyphenylacetylene

Steric tuning of silylacetylenes and chiral phosphine ligands for rhodium-catalyzed asymmetric conjugate alkynylation of enones.

Rhodium-catalyzed asymmetric conjugate addition to R,âunsaturated ketones and related compounds is now well-recognized to be one of the most efficient methods of introducing aryl and alkenyl groups with high enantioselectivity.1 On the other hand, asymmetric conjugate addition of alkynyl groups has not been welldeveloped in spite of its high synthetic utility.2 A most straightforward and conven...

Phosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones

Novel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is a-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design al...

New phosphine-diamine and phosphine-amino-alcohol tridentate ligands for ruthenium catalysed enantioselective hydrogenation of ketones and a concise lactone synthesis enabled by asymmetric reduction of cyano-ketones

Enantioselective hydrogenation of ketones is a key reaction in organic chemistry. In the past, we have attempted to deal with some unsolved challenges in this arena by introducing chiral tridentate phosphine-diamine/Ru catalysts. New catalysts and new applications are presented here, including the synthesis of phosphine-amino-alcohol P,N,OH ligands derived from (R,S)-1-amino-2-indanol, (S,S)-1-...

Asymmetric hydrogenation with antibody-achiral rhodium complex.

Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.