Asymmetric Dual Enamine Catalysis/Hydrogen Bonding Activation

Asymmetric enamine base activation of carbonyl compounds is a well-known and widely used strategy for providing functionalization organic in an efficient way. The use solely substances, which most cases are commercially available primary or secondary amines that easy to obtain, avoids the hazardous substances metal traces, making this type catalysis highly convenient methodology from sustainable point view. In many cases, reactivity stereoselectivity obtained far being practical advantageous strategy; can be improved by using hydrogen bonding co-catalyst help during one species bifunctional catalyst direct approximation reagents reaction outcome. review, we describe methodologies make dual performing α-functionalization (enamine activation) remote (such as dienamine trienamine compounds.