Astrovirus Pathogenesis

Astrovirus Pathogenesis

Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge...

A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus

Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agen...

Astrovirus Diagnostics

Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised indiv...

Astrovirus Replication: An Overview

Human astroviruses are important pathogens that cause gastroenteritis worldwide. Significant progress has recently been made regarding the characterization of the RNA replication process, the apoptotic response induced in virus-infected cells, and the formation of virus-like particles. First, a relationship between astrovirus RNA replication sites and the endoplasmic reticulum-derived membranes...

Rotavirus and Astrovirus