Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Neurotoxicity is a major side effect of platinum derivatives both during and after treatment. In the absence of effective pharmacological compounds, the opportunity to identify safe adjuvant treatments among medicinal plants seems appropriate. Astragali radix is an adaptogenic herbal product recently analyzed in platinum-treated cancer patients. With the aim of evaluating the anti-neuropathic p...

Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction v...

Organic Farming by Using Different Desert Soiles Could it be an Alternative to Fertilizers?

It is shown that Saharan soil has the potential of producing bioavailable iron when illuminated with visible light and also it contains some essential macronutrient and micronutrient elements. In this study, these properties of the desert soil were tested on the certified wheat cultivars (Triticum aestivum L. var. gonen 98) using Hewitt nutrient solution, illuminated and non-illuminated soil so...

Could it be Lyme neuroborreliosis?

Management of oxaliplatin-induced peripheral neuropathy

Neurotoxicity is the most frequent dose-limiting toxicity of oxaliplatin. Acute sensory neurotoxicity manifests as rapid onset of cold-induced distal dysesthesia and/or paresthesia, sometimes accompanied by cold-dependent muscular contractions of the extremities or the jaw. The symptoms, often occurring during or shortly after infusion, are usually transient and mild. A cumulative sensory perip...