Associations of Independent IL2RA Gene Variants with Intermediate Uveitis
نویسندگان
چکیده
منابع مشابه
Associations of Independent IL2RA Gene Variants with Intermediate Uveitis
PURPOSE The genetic background for the concomitance of uveitis and other autoimmune diseases remains elusive. Here the role of two IL2RA gene variants (rs11594656 and rs12722495) was investigated in intermediate uveitis and HLAB27 acute anterior uveitis. MATERIALS AND METHODS One hundred fifty-nine patients with HLAB27 acute anterior uveitis, 85 patients with intermediate uveitis, 138 HLAB27 ...
متن کاملIntermediate Uveitis
A 32-year old woman presented with visual loss in her right eye on8/9/95. She was diagnosed with bilateral pars planitis with vitreoushemorrhage and inferior snowbank in the left eye in 1986. Subsequently she developed rhegmatogenous retinal detachment in that eye. Pars plana vitrecromy with endolaser panretinal photocoagulation (PRP) and scleral buckling OS was done. One year later she had cat...
متن کاملAssociation of the IL2RA/CD25 Gene With Juvenile Idiopathic Arthritis
OBJECTIVE IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). T...
متن کاملIntermediate uveitis in Indian population
PURPOSE Intermediate uveitis (IU) is generally believed to be autoimmune in nature requiring systemic corticosteroid and immunomodulatory therapy. This belief stems from the published reports from the developed countries; and the scenario maybe different in the developing countries that maybe endemic for certain infections. There are no large series available on the etiologic causes of intermed...
متن کاملAssociation study of IL2RA and CTLA4 Gene Variants with Type I Diabetes Mellitus in children in the northwest of Iran
Introduction: A variety of genetic predisposing factors and environmental factors are known to influence the pathogenesis of type-1 diabetes (T1D). This study intended to investigate the association of cytotoxic T-lymphocyte associated protein 4 (CTLA4) and interleukin 2 receptor subunit alpha (IL2RA) gene polymorphisms with type 1 diabetes in children of northwest of Iran. Methods: Genomic DNA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0130737