Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort

Background Allergy, the most frequent immune disorder affecting 30% of world's population, is consequence immunoglobin E (IgE) sensitization to allergens. Among genetic factors suspected be involved in allergy, HLA class-II genomic region a strong candidate. Objective To assess association between alleles and specific IgE (sIgE) large number respiratory allergen molecules. Methods The analysis relied on 927 participants EGEA cohort, including 497 asthmatics. study focuses 26 aeroallergens recognized by sIgE at least 5% population (determined with MEDALL chip ? 0.3 ISU) 23 imputed alleles. For each allele, we fitted logistic regression model accounting for familial dependence adjusted gender, age, principal components. p-values were corrected multiple comparisons (False Discovery Rate). Results Most 19 statistically significant associations observed regard pollen allergens (mugwort Art v 1, olive tree Ole e timothy grass Phl p 2, 5 plantain Pla l 1), three mold (Alternaria Alt single one regards house dust mite (Der 7). No was pet strongest found mugwort 1 (OR = 5.42 (95%CI, 3.30; 8.88), 4.14 (2.65; 6.47), 3.16 (1.88; 5.31) DQB1*05:01, DQA1*01:01 DRB1*01:01, respectively). Conclusion Our results support important role as response genes predisposing their carriers various major