ASSOCIATIONS BETWEEN SLEEP AND REST: ACTIVITY CHARACTERISTICS AND METABOLOMIC PROFILES IN OLDER MEN

Abstract The association of sleep and rest-activity rhythms (RAR) with metabolic health is not fully understood. Previous studies have identified multiple metabolite markers in amino acid lipid pathways associated various characteristics sleep. However, most the used self-reported sleep, limited examined 24-hour RAR profiles, a more complete picture activity. We studied 950 older men measured metabolomics from fasting blood samples. numerous metabolomic that were cross-sectionally actigraphy-based measures (total time, efficiency, timing) (amplitude, acrophase, mesor overall rhythmicity). majority metabolites acids lipids wide range pathways, including metabolism branched chain metabolism, fatty acids, gamma-glutamyl acids. Our preliminary findings suggest are widely involved human metabolism.