Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa

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Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa.

Purpose Our earlier study showed that the width of the intact ellipsoid zone (EZ) of the photoreceptors was significantly but weakly correlated with the amplitudes of the focal macular ERGs (FMERGs). The aim of this study was to determine a microstructure of the photoreceptors in the spectral-domain optical coherence tomographic (SD-OCT) images that was more strongly correlated with the FMERG p...

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Focal cone electroretinograms in dominant retinitis pigmentosa with reduced penetrance.

Focal electroretinograms (ERGs) from the green and red cone systems in combination were elicited with a method of rod silent substitution from three young patients with dominant retinitis pigmentosa with reduced penetrance. With this method, two alternating lights of different wavelength, matched in brightness for the rods, were presented to the same retinal area. The brighter light for the gre...

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Correlation between macular volume and focal macular electroretinogram in patients with retinitis pigmentosa.

PURPOSE To determine whether a significant correlation exists between the morphology of the macula measured by optical coherence tomography (OCT) and the amplitude of focal macular electroretinograms (fmERGs) in patients with retinitis pigmentosa (RP). METHODS fmERGs were recorded in 43 patients with RP and 43 age-similar normal subjects, with a 15 degrees stimulus spot, 5.6 to 5.8 mm in diam...

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Automated segmentation of outer retinal layers in macular OCT images of patients with retinitis pigmentosa

To provide a tool for quantifying the effects of retinitis pigmentosa (RP) seen on spectral domain optical coherence tomography images, an automated layer segmentation algorithm was developed. This algorithm, based on dual-gradient information and a shortest path search strategy, delineates the inner limiting membrane and three outer retinal boundaries in optical coherence tomography images fro...

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Negative electroretinograms in retinitis pigmentosa.

PURPOSE Patients with typical clinical features of retinitis pigmentosa were found to have the atypical electroretinographic finding of a negative waveform to a bright flash in the dark-adapted state. The full-field electroretinogram (ERG) was studied in seven such patients to understand better the pathophysiology. METHODS Rod ERGs were isolated using blue and red flash stimuli in the dark-ad...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2017

ISSN: 1552-5783

DOI: 10.1167/iovs.17-22040