Association of Self-Rated Pain with Clinical Peri-Implant Parameters and Cytokine Profile in Smokers and Never Smokers with and without Peri-Implantitis

To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, biomarker levels among smokers never with without peri-implantitis. Sixty individuals (20 peri-implantitis [group-1], 20 [group-2] [control-group]) were included. SPP was evaluated using a numeric rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), bleeding on (BOP) recorded. After obtaining samples, of TNF-α, MMP-1, IL-8 measured. The mean score in group-1, group-2, control group 1.3 ± 1, 3.4 zero, respectively. PD (p < 0.05), BOP PI crestal bone loss (CBL) 0.05) significantly higher test groups than group. raised group-1 group-2 A significant correlation increasing PICF observed based regression analysis. Proinflammatory biomarkers peri-implantitis, proinflammatory cytokines SPP.