Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni

Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni.

The antischistosomal activity of clonazepam, when administered alone or in association with oxamniquine and praziquantel, was experimentally evaluated in mice infected with Schistosoma mansoni. The animals were treated 45 days post-infection with a single dose, by oral route, according to three treatment schedules: clonazepam 25 mg/kg and sacrificed 15 min, 1h or 4 h after treatment; clonazepam...

Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni.

The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni. Forty days after infection, mice were treated with lovastatin, 400 mg/kg for five consecutive days by oral route, and on the last day of this sequence with 50 mg/kg oxamniquine or with 200 mg/kg praziquantel, both by oral route, single d...

Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil.

A rândomized clinicâl trialÏvas carried out to compâ¡e the efficâcy ofa low-dosage combinâtion of oxâmniquine (7.5 mg/kg) plus prâziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of schistosomiâsis mansoni in the Brazilian north-east. The drugs v¡ere rândomly administered per os to 91 patients. Six and twelve months after treat...

Synergy of concurrent low dose oxamniquine and praziquantel in schistosomiasis.

Treatment of patients with schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine.

A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups. One was treated with praziquantel, 55 mg/kg of body weight CBWT), and the other one with oxamniquine, 15mg/kg bwt, administered in a single oral dose. The diagnosis and th...