Association of Low Alanine Aminotransferase Values with Extubation Failure in Adult Critically Ill Patients: A Retrospective Cohort Study

Background: Liberation from mechanical ventilation is a cardinal landmark during hospitalization of ventilated patients. Decreased muscle mass and sarcopenia are associated with high risk extubation failure. A low level alanine aminotransferase (ALT) known biomarker sarcopenia. This study aimed to determine whether levels ALT increased failure among critically ill Methods: was retrospective single-center cohort mechanically patients undergoing their first extubation. The study’s outcome within 48 h 7 days. Multivariable logistic Cox regression were performed an independent predictor these outcomes. Results: included 329 median age 62.4 years (IQR 48.1–71.2); 210 (63.8%) at for 66 (20.1%) 83 (25.2%) failed the attempt after days, respectively. Low values more common requiring reintubation (80.3–61.5% vs. 58.6–58.9%, p < 0.002). analysis identified as ? 21 IU/L had adjusted hazard ratio (HR) 2.41 (95% CI 1.31–4.42, 0.001) 16 HR 1.94 1.25–3.02, Conclusions: ALT, established frailty, factor hospitalized simple laboratory parameter can be used effective adjunct predictor, along other weaning parameters, thereby facilitate identification high-risk