Association of laboratory parameters and genetic polymorphisms with ischemic stroke in Chinese Han population

Numerous genetic polymorphisms and clinical laboratory parameters are associated with ischemic stroke (IS). However, the results of such studies have frequently been inconsistent. The aim present study was to evaluate associations between that influence risk IS in a Chinese Han population. Clinical were measured by an automatic biochemical analyzer. Genotype allele frequencies angiotensin‑converting enzyme (ACE) D/I, methylene tetrahydrofolate reductase (MTHFR) C677T β‑fibrinogen (β‑Fg) A/G, 455/148T/C characterized restriction fragment length polymorphism‑PCR. Furthermore, gene plasminogen activator inhibitor (PAI)‑1-4G/5G apolipoprotein E (ApoE) ε2,3,4 allele‑specific PCR. genotype six genes different groups analyzed chi‑square tests. distribution maps compared control group 336 healthy individuals 762 patients IS. Certain ACE I/D, β‑Fg‑455 A/G PAI‑1 4G/5G. D I/D high levels total cholesterol low‑density lipoprotein (LDL‑C). fasting blood glucose, triglyceride LDL‑C factors for There significant differences β‑Fg‑148 T/C group. In conclusion, IS‑related genes. support determination range values common genotypes diabetes hyperlipidemia as strategy early prevention