Association of HDL subfractions with cardiovascular risk in Hungarian general and Roma populations

Abstract Background High-density lipoprotein (HDL) cholesterol levels are inversely associated with cardiovascular risk (CVR). However, HDL is not a homogeneous lipid and can be subdivided into subfractions, which uniformly CVR. Among Roma populations, the prevalence of reduced and, consequently, that diseases very high. it known how this reduction affects different subfractions whether changes in their representation Methods The study aimed to investigate there difference subfraction profile between Hungarian general (HG) populations determine association CVR estimated by Framingham Risk Score (FRS) Systematic COronary Evaluation (SCORE) algorithms. was separated using Lipoprint system, separates 10 three classes: large (HDL-L), medium (HDL-I), small (HDL-S). Analyses were carried out on samples 100 control subjects (50 50 individuals normal profiles) 277 HDL-C levels. Results Our results show has overall profile, significant decreases HDL-6, -7. Regardless estimation method, elevated (in mmol/L) HDL-1 3 HDL-L significantly risk. A higher %) have risk-reducing, while HDL-8 risk-increasing effect FRS. Conclusions our protective lower increased CVR, suggesting distribution contributes unfavourable Roma. Key messages • Levels HDL-6 -7 population than one. among them.