Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis

Objectives Gay matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes. Methods Clinical MRI data were obtained at 8 European sites from 170 healthy controls (HCs) 398 patients with (34 isolated syndrome [CIS], 226 relapsing-remitting [RRMS], 95 secondary progressive [SPMS], 43 primary [PPMS]). Fifty-seven HCs 144 underwent follow-up. Baseline loss, progression, correlations disability clinical worsening assessed. Results SBM identified 26 cerebellar, subcortical, sensory, motor, cognitive components. was found vs almost all components ( p range <0.001–0.04). Compared to HCs, CIS showed circumscribed temporal, salience atrophy, while RRMS exhibited widespread atrophy. Cerebellar, sensorimotor, salience, frontoparietal PPMS SPMS those RRMS. At 1 year, 21 (15%) had worsened. progressed fronto-temporo-parietal higher associated R 2 = 0.65) baseline lower normalized brain volume (? ?0.13, 0.001), greater sensorimotor ?0.12, 0.002), longer disease duration 0.09, 0.04). (odds ratio 0.98, 0.008) cerebellar 0.40, 0.01) independently predicted (area under the curve 0.83). Conclusion differed phenotypes year MS. In addition global measures, explained worsening.