Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications
نویسندگان
چکیده
منابع مشابه
Oxidative stress and diabetic complications.
Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium. This increased superoxide production causes the activation of 5 major pathways involved in the pathogene...
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Bio Design l Vol.2 l No.1 l March 31, 2014 INTRODUCTION Diabetes mellitus comprises a number of chronic metabolic diseases characterized by hyperglycemia due to absolute or relative insulin deficiency. Hyperglycemia is only the most obvious biochemical marker of these complex disorders that affect carbohydrate, lipid, protein, and electrolyte metabolism and may impair numerous organs and functi...
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The aim of this article is to evaluate the pros and cons of a specific impact of postprandial hyperglycemia and glycemic variability on the--mainly cardiovascular (CV)--complications of diabetes, above and beyond the average blood glucose (BG) as measured by HbA(1c) or fasting plasma glucose (FPG). The strongest arguments in favor of this hypothesis come from impressive pathophysiological studi...
متن کاملAssociation of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit.
OBJECTIVE We evaluated retrospectively plasma glucose levels and the degree of hypoglycemia, hyperglycemia, and glucose variability in a PICU and then assessed their association with hospital length of stay and mortality rates. METHODS Electronic medical records at the Packard Children's Hospital at Stanford University were reviewed retrospectively for all PICU admissions between March 1, 200...
متن کاملLong-term study of the association of adipokines and glucose variability with diabetic complications
BACKGROUND/AIMS Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. METHODS A tot...
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ژورنال
عنوان ژورنال: Journal of Diabetes Research
سال: 2020
ISSN: 2314-6753,2314-6745
DOI: 10.1155/2020/7489795