Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression
نویسندگان
چکیده
منابع مشابه
Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression
BACKGROUND A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression. METHODS In a case-contr...
متن کاملAssociation of FCγRIIA (CD32) polymorphism with susceptibility to brucellosis
Background: Brucellosis is the major bacterial zoonoses of global importance caused by Brucella spps. FCγRIIA receptor plays a central role in phagocytosis of IgG2-opsonized bacteria. FCγRIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. Cells expressing Fc γ RIIa-H131, bind more efficiently to complexes of IgG2 than those expressi...
متن کاملEvaluating disease severity in idiopathic pulmonary fibrosis.
Accurate assessment of idiopathic pulmonary fibrosis (IPF) disease severity is integral to the care provided to patients with IPF. However, to date, there are no generally accepted or validated staging systems. There is an abundance of data on using information acquired from physiological, radiological and pathological parameters, in isolation or in combination, to assess disease severity in IP...
متن کاملCollagen polymorphism in idiopathic chronic pulmonary fibrosis.
Collagens in normal human lung and in idiopathic chronic fibrosis were investigated in terms of their covalent structure and compared for possible alterations in the diseased state. Collagens were solubilized by limited digestion with pepsin under nondenaturing conditions, and after purification they, were fractionated into types I and III. Carboxymethylcellulose and agarose chromatography of b...
متن کاملTNFα Gene Polymorphism in Idiopathic Pulmonary Fibrosis
Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a chronic inflammatory process and abnormal wound healing. Tumor Necrosis Factor alpha (TNFα) is considered to play a key role in fibroblast proliferation and increased collagen synthesis. It appears that there is a genetic predisposition to IPF. The genetic associations of TNF-α with IPF have been reported in different cohorts...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Pulmonary Medicine
سال: 2010
ISSN: 1471-2466
DOI: 10.1186/1471-2466-10-51