Association of cytokines gene polymorphisms (TNF and IL8) with chronic obstructive pulmonary disease development
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چکیده
منابع مشابه
Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is characterized by airway epithelial damage, bronchoconstriction, parenchymal destruction and mucus hypersecretion. Upon activation by a broad range of stimuli, transient receptor potential vanilloid 4 (TRPV4) functions to control airway epithelial cell volume and epithelial and endothelial permeability; it also triggers bronchial smooth muscle cont...
متن کاملGene polymorphisms and chronic obstructive pulmonary disease
The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, sever...
متن کاملAssociation between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the prot...
متن کاملassociation of cytokine gene polymorphisms with chronic obstructive
the aim of this study was to examine the association of 22 cytokine gene polymorphism in macedonians with chronic obstructive pulmonary disease (copd). the sample of the population comprised of 301 normal respondents and 62 patients with copd. cytokine genotyping was performed by polymerase chain reaction with sequence-specific priming (pcr-ssp). positive (susceptible) association was found bet...
متن کاملChronic obstructive pulmonary disease and cytokines.
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality. Understanding what happens at a cellular level will lead to more effective treatments. Interleukins and transforming growth factor-beta are important inflammatory mediators that may be significant in the evolution of chronic obstructive pulmonary disease.
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ژورنال
عنوان ژورنال: Bulletin of Siberian Medicine
سال: 2010
ISSN: 1819-3684,1682-0363
DOI: 10.20538/1682-0363-2010-3-91-97